The epic tale of an American family, Flesh and Blood follows three generations of the Stassos clan as it is transformed by ambition, love, and history. Constantine Stassos, a Greek immigrant, marries Mary Cuccio, an Italian-American girl, and they have three children, each fated to a complex life. Susan is oppressed by her beauty and her father's affections; Billy is brilliant, and gay; Zoe is a wild, heedless visionary. As the years pass, their lives unfold in ways that compel them--and their parents--to meet ever greater challenges.