Venice, 1734. Castrato soprano Tito Amato has let fame go to his head. Neglecting his vocal practice for dubious pleasures, Tito finds himself demoted to secondary roles and overshadowed by a visiting star. When the murder of scene painter Luca Cavalieri threatens to close the opera house, Tito jumps at the chance to regain his chance to reclaim his status by finding the killer.

The hunt for the person who wears the mask of Palantinus carries Tito and Augustus "Gussie" Rumbolt, an Englishman making his Grand Tour, into the treacherous depths of the city dedicated to masquerade and pleasure and reveals many facets of its multiple religious faiths.

In September of 1740, singer Tito Amato receives a curious invitation. The German composer Karl Johann Weber is rehearsing a new opera at an isolated villa nestled in the hills of the Venetian mainland. Would Tito accept the lead role? Puzzled by the air of secrecy that enshrouds the production, but attracted by a generous fee, Tito agrees. Artist Gussie Rumbolt, Tito's friend and brother-in-law, has also been summoned to paint scenes of the estate's grape harvest. The two men find the countryside awash with the golden hues of autumn, but the bucolic mood quickly turns menacing when a notorious figure from Tito's past turns up at the villa. That night, at the stroke of twelve, a soprano stumbles over a stranger who has been beaten to death with the clock pendulum. With the local constable away on a boar hunt, the midnight murderer strikes with impunity, raising terror to a fevered crescendo. Ever faithful to the ideals of truth and justice, Tito pursues his own quest for answers-a quest that leads straight into the painful secrets of his heart and beyond. The Iron Tongue of Midnight is the fourth novel in Myers' Baroque Mystery series. It follows Cruel Music.