Hellboy creator Mike Mignola finally reveals Abe Sapien's bizarre history. Introduced in the first Hellboy book and featured prominently in the film, Abe Sapien has remained one of the most intriguing mysteries of Mignola's celebrated work. The recent Hellboy film steered clear of any origin story for Abe so that the tale could be told in Plague of Frogs. The story of Abe's origins unfolds as the Bureau for Paranormal Research and Defense try to stop the monstrous frog men from the first Hellboy graphic novel, Seed of Destruction. The plague begins its spread across America, lending an apocalyptic new direction to Mignola's stories.

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