Oxford and Lafayette County were formed from the Pontotoc Treaty and the Chickasaw Cession of 1832 and the revised agreement in 1834. This treaty with the Chickasaws ceded land that formed 12 counties in North Mississippi. On June 22, 1836, three land speculators, John Martin, John Chisom, and John Craig, donated 50 acres to the Board of Police for the formation of the city of Oxford. The name Oxford was proposed by a nephew of John Craig, Thomas D. Isom, who worked for him in his trading post, in hopes that the state legislature would place the new state university there. Oxford was chartered by the State of Mississippi on May 11, 1837. The University of Mississippi opened its doors in 1848.

Oxford and Lafayette County were formed from the Pontotoc Treaty and the Chickasaw Cession of 1832 and the revised agreement in 1834. This treaty with the Chickasaws ceded land that formed 12 counties in North Mississippi. On June 22, 1836, three land speculators, John Martin, John Chisom, and John Craig, donated 50 acres to the Board of Police for the formation of the city of Oxford. The name Oxford was proposed by a nephew of John Craig, Thomas D. Isom, who worked for him in his trading post, in hopes that the state legislature would place the new state university there. Oxford was chartered by the State of Mississippi on May 11, 1837. The University of Mississippi opened its doors in 1848.